Houston Oilers @ Cleveland Browns

1. Dallas Cowboys @ Washington Redskins1980-09-08 2. Los Angeles Rams @ Tampa Bay Buccaneers1980-09-11 3. Houston Oilers @ Cleveland Browns1980-09-15 4. New York Giants @ Philadelphia Eagles1980-09-22 5. Denver Broncos @ New England Patriots1980-09-29 6. Tampa Bay Buccaneers @ Chicago Bears1980-10-06 7. Washington Redskins @ Denver Broncos1980-10-13 8. Oakland Raiders @ Pittsburgh Steelers1980-10-20 9. San Diego Chargers @ Dallas Cowboys1980-10-26 10. Miami Dolphins @ New York Jets1980-10-27 11. Chicago Bears @ Cleveland Browns1980-11-03 12. New England Patriots @ Houston Oilers1980-11-10 13. Oakland Raiders @ Seattle Seahawks1980-11-17 14. San Diego Chargers @ Miami Dolphins1980-11-20 15. Los Angeles Rams @ New Orleans Saints1980-11-24 16. Denver Broncos @ Oakland Raiders1980-12-01 17. Pittsburgh Steelers @ Houston Oilers1980-12-04 18. New England Patriots @ Miami Dolphins1980-12-08 19. Dallas Cowboys @ Los Angeles Rams1980-12-15 20. Pittsburgh Steelers @ San Diego Chargers1980-12-22 21. 1981 ProBowl AFC vs NFC1981-02-01